Yahoo Reaction Paper

On the 3rd of May, 2012, Daniel Loeb, Yahoo's largest external shareholder, who then controlled 5. % of the company through his hedge fund – Third point, launched an attack on Yahoo! And its new C. E. O. , alleging that Scott Thompson had lied on his resume about his academic qualifications. This was a result of a proxy war between Yahoo! And Loeb, who being a major stakeholder, wanted his choice Of candidates on the board and saw Thompson as an obstacle. These allegations snowballed into a huge crisis during a trying period for the organization.After rejecting a profitable takeover bid from Microsoft, steep competition from other internet giants and top level management issues, this situation weakened the company rather. Thompson, in his resume, claimed to have a college degree in accounting and computer science from Stonewall College near Boston. This â€Å"claim† was published on the company's bio and annual report, a legal document whose validity and authenticity is confirmed by the CEO- He even certified these degrees in the Securities and Exchange Commission filings.After receiving Lobe's letter stating that Thompson only had an accounting degree from Stonewall and the college didn't even offer a computer science degree at the time, Yahoo! Initiated an investigation. Upon receiving the findings of the investigation, Yahoo! Encoded that Thompson in fact only had an accounting degree and called the mistake an â€Å"inadvertent reproof. F-judging information on ones resume is something that many people indulge in, in order to make their profiles appealing especially in competitive job markets, a place where they fear loss to other capable candidates.Scott Thompson probably didn't need to lie about this particular qualification as he was in fact more than capable to lead Yahoo! Given his past experiences in technology firms like Papal and Visa. In my opinion, one of the most important methods of moral reasoning that one must adopt while making any professional or even personal decision, is the Rawlins Liberalism moral method. As Minnie Moldavia rightly suggests, one should keep in mind that the decisions you make could eventually decide your social position in the future.This future could not just have a positive or negative effect on you, but also the others who depend on and matter to you. Had Scott Thompson followed this method while making his resume as opposed to just a consequentiality approach, it is very likely he wouldn't have found himself in such a controversy. This saga did not just affect him, but also the organization, its shareholders and employees. Since Loeb first revealed Thompson padded resume, Yahoo's shares fell by around 3%. Since his tenure began, Thompson began to cut costs by laying off almost 14% of the Yahoo! Rockford, most of whom were in fact engineers and computer science graduates. Although the â€Å"Resume-Gate† seemed to some a minor error blown out of proportion, several disgruntle d Silicon Valley employees questioned how they could work for an organization where the C. E. O. Claimed to be a computer scientist and actually wasn't. Employee and share-holder morale was at an all-time low, a situation caused by a decision made many years ago, which Thompson rabble thought would never come back to haunt him. Thompson is not alone. There have been other C. E.Co's who have lied about their credentials in the past and some have almost got away with it. Ronald Carmella, C. E. O of Bausch & Lomb, admitted to his mistakes and retained his position. Others like David Edmondson from Radiograms haven't been so lucky. In the name of marketing or branding themselves, people believe they can attract aspirations jobs and seem appealing to employers. More often than not, people do not need these little lies to achieve success or the job of their dreams. David Edmondson, for example, had climbed up the company ladder and had become C. E. O. Cause of his ability and skillet, not because of the degree he showcased on his resume. Radiograms may have been too harsh when they implemented their decision, but it was definitely for the long term stability of the company. From the observations so far, understand that the active agents are the board of directors at Yahoo, Scott Thompson and Daniel Loeb. Their decisions will affect the passive agents I. E. The shareholders and the employees. So were Yahoo! And Radiograms justified in asking their prized possessions to move on? As a decision maker, the questions one must ask, according to Graham Tucker, are as follows.Is the decision Profitable? On firing Scott Thompson without cause, Yahoo! Would have to pay him a huge severance fee and stock grants of up to $million. This would seem a huge compensation and a loss for the organization in the short term, but could definitely seem profitable in the near future as the stock prices were bound to increase, which they did upon Thompson resignation. Tucker also asks if the decision is legal. The answer to that is also yes. According to the Serbians-Solely Act of 2002, violators face penalties of 20 years in prison and nines of up to $million if the data submitted to the SEC isn't authentic.Fairness of the decision is another question that Tucker asks. According to the Yahoo's code of ethics, all employees are expected to disclose fair, accurate, timely and understandable information in reports and documents filed to the S. E. C. This applies even to directors. It would be unfair to other employees if such conduct ignored what the top level management was up to. The decision of firing Thompson was also the right decision as this would not just set a strict precedent at Yahoo, but it would also salvage the company from a trying tuition.No company would want their leader lying about anything let alone something as petty as three words on their resume. Trust issues creep in and shareholders could question the transparency and openness the company has to offer. Lastly, Tucker asks if the decision taken would ensure further sustainable development. I personally believe that during this predicament, in spite of multiple changes in management a few years earlier, a good change would benefit Yahoo's future growth. A situation like this sets a bad tone at the top and beginning afresh would uplift employee and shareholder morale.

Personal Philosophy of Classroom Management Essay

Classroom Management is an essential element in implementing a successful learning environment for students. A teacher who implements a classroom management plan will control student’s misbehavior so that all students will be focused on the lessons being taught in the classroom. Below is an annotated list of points that I believe in concerning my view of classroom management. 1. How teacher should act: * Enthusiastic- A teacher should show enthusiasm when she is teaching the lessons. The teacher needs to show that she is excited about teaching the lessons so that the students will stay interested in listening and understanding the subject area content. * Respectful- The teacher should treat students with respect and also demand respect. She should never use fowl language, inappropriate behavior, share too much personal information or act in ways that are not ethical. * Role Model- A teacher should act as a role model to her students. The teacher should not do anything that would jeopardize her career as a teacher that would make her students look down upon her. She also must live a life that students look up to so they will remember that teacher forever. * Patiently- A teacher must exhibit patience in class. Every student learns at different paces and at different levels. A teacher must be willing to be patient if the students are not grasping the information. She should explain the information to the students until they finally understand the lesson 2. How students are expected to behave: * Respectful- Students are to be respectful towards the teacher and to each other. Students should show respect to the teacher by not talking when the teacher is instructing the class. The students should show respect to each other by not hitting each other, making fun of another, or taking one’s personal belongings. * On Task-Students should stay on task in class. Students should be focused on the teacher’s lessons and instructions. They should not be wandering off getting off task. If the students are off task, they will not understand the lessons or remember what happened in class. Also the teacher will have to go back and teach the lesson again which can cause the teacher to be off target teaching the curriculum and it will result in student’s receiving poor test scores. * Appropriately Well Behaved- Students should be well behaved in class. It is important for students to understand the importance of good behavior. If students are well behaved in the classroom, the teacher can spend more time instructing the students than time spent on behavioral issues. In a well behaved classroom, students are able to learn effectively. * Academically Prepared- Students are to come to school academically prepared. The students should complete their homework assignment each day in order to make sure they understand the subjects that are being taught. They should always come prepared to listen to the subject matter, offer their opinions, and ask god questions in class. 3. What the classroom might look and feel like: * Engaging- The classroom should look and feel engaging to the student. In the classroom, the teacher can arrange the classroom that promotes student interaction and group collaboration. Students should be seated in a circle or horseshoe shape that maximizes the amount of eye contact students can have with each other. * Clean and Organized Classroom- A teacher’s classroom should be clean and organized. The school supplies should be neatly organized and in a safe place where students can safely access the supplies. * Filled with student’s work- The classroom should be filled with student’s work on projects. The students will feel comfortable and engaged if what they are learning in class will be showcased in the classroom. The student can look around the room and be reminded to always do their best on their assignments. This also sends a message to students that their work and learning is important. * Student Centered – The classroom should be focused on the students. In the student centered classroom, you will find workstations that promote group activities such as puzzles or brainteasers that promote student collaboration. 4. How the teacher helps students conduct themselves properly: * Demonstrating the Rules- The teacher should teach, review, and practice rules form beginning of school till the end of school. The teacher should also let students demonstrate good behaviors and bad behaviors so that students will understand how to follow the rules and to have good behavior in class. * Reinforce positive behavior with Incentives- A teacher can help students conduct themselves properly by providing incentives through positive behavior. A student who exhibits positive behavior weekly will pick a price out of the treasure chest. This will result in students with bad behavior to act better if they see students winning cool prizes. * Student and Parent Contracts- To ensure students are behaving properly, student and parent contracts are sent home for parents and students to sign. This contract outlines what is expected from the student’s behavior, academics, and the parent’s commitment in the child’s education. This will be very helpful in helping the students have good behavior in class. * Character Education Mini Lessons tied to Curriculum- Teachers can tie in the classroom rules and good behavioral skills as mini-lessons. Before teaching the lessons, the teacher can discuss how to treat others, how to walk quietly in the halls, and do not talk while others are talking. By having these mini lessons on how students should behave will remind them of how to have good behavior in class. 5. What the teacher should do about misbehavior: * Cues- Teachers uses a cue or a simple verbal reprimand to redirect a student’s focus which eliminates the inappropriate behavior. A teacher can also praise the efforts of students with good behavior which can reduce the misbehavior among the other students. * Consequences such as loss of recess- If a student keeps misbehaving, the teacher can use the consequence of loss recess. The majority of students like to go to recess. If the student knows their punishment by loss of recess due to their misbehavior, their behavior will improve. * Private conference with student- If the student still misbehaves, the teacher will need to talk with the student. The teacher will inform the student that his or her misbehavior will not be tolerated in class and his or her parents will be contacted if the misbehavior continues. * Contact parent- A teacher should contact the parents if the student keeps misbehaving in class. If the teacher lets the parents know how their child behaves in class, then the parents can also talk to the child and discipline them at home. 6. How students should be taught and what is expected of them: * Post rules in the classroom- Teachers can post rules in the classroom so that students can be reminded each day of how to properly behave in class. Also the teacher can give quizzes to students about the poster rules throughout the year. * Clear articulation and communication in the syllabus- Teachers should communicate clearly about what is expected of student’s assignments and their behavior in class. For example, informing students to always do their best on their work or their handwriting must be neat on all of their assignments should be clearly communicated. Creating a syllabus will also inform students of when their assignments are due.

Consumer' Income Coursework Example | Topics and Well Written Essays - 1000 words

Consumer' Income - Coursework Example When the price of the orange is $30, consumers are willing and able to buy 30,000 oranges. As the price of the orange decrease to $10 the quantity demanded increases to 60,000 oranges which are due to the fact that more consumers will be willing to buy that orange. For a linear curve decrease in price is directly proportional to increase in quantity demanded. 7. List the determinants of demand. (6 total)   The determinants of demand curve are as follows: a) The consumer’s income b) The price of related goods c) Advertisement d) Consumer price expectation e) Number of consumers in the market f) Taste and preference of consumers 8. Next to each determinant in your list give a real world example of it.   Along a demand curve the factors, other than price of the good, are held constant. When these factors change the demand curve shifts either outwards or inwards which means that either more or less is demanded at a certain price. An explanation of these factors is given below: 1- The consumer’s income: the effect that income has on the amount of a product that consumers are willing and able to buy depends on the type of good. For most goods, there is positive (direct) relationship between a consumer’s income and the amount of the good that one is willing to buy (Campbell R. McConnell, 2007). The demand for a product will shift outward when the consumer’s income rises. We call these types of goods as normal goods. For example, the demand for branded clothes increases with the income level. However; for some goods the relationship is opposite between income and your demand for a product. These goods are called inferior goods. There demand decreases as income increases. For example, income level increase will cut the demand for second hand cars. 2- The price of related goods: A common example could be of bagels and cream cheese. We call these types of goods complements. If the price of a bagel goes up, the law of demand tells us that on e will buy fewer bagels. Moreover, as use of cream cheese is complimentary to bagels, the demand for cream cheese will also fall. When two goods are complementary, there is an inverse relationship between the price of one good and the demand for the other good. On the other hand, some goods are considered to be substitutes for one another. This means that they can be used as an alternate to each other. Either of them would be deferred for the other. For example, Coke and Pepsi are used as substitutes for each other. If price of Coke increase, the demand for Pepsi will increase and if the price of Coke decreases the demand of Pepsi will decrease. This portrays a positive relationship between the price of one good and the demand for the other good. 3- The tastes and preference of consumers: It is a less tangible item that can have a big impact on demand. There are certain things that can change one’s taste or preferences which ultimately causes people to buy more or less of a p roduct. For instance, a person may have a higher demand for an umbrella on a rainy day than on a sunny day. Another example of it would be endorsements by celebrities. If a celebrity endorses a new product, this may increase the demand for a product. This will change the preference of a consumer and will result in an increase in demand. On the other hand, if a new health study comes out indicating that meat is bad for your health, this may decrease the demand

Art Essay Example | Topics and Well Written Essays - 500 words

Art - Essay Example The spaces do not look constricted or wide. The spaces are arranged in a manner that makes the fishes look as though they are passing by the viewer. The lines are sharp, well-defined, thin, angular, and curved. The texture looks natural and real, reinforced by the colors and specks of light. The image has a combination of asymmetrical balance and radial balance. Asymmetrical because when you look at the image there is a sense of greater weight at the left side but then the central object, which is the biggest fish wearing a rhino mask, sustains the balance, creating a radial balance. The emphasis is on the central object. It dominates the image by being darker, heavier, and spacious than the other objects—the other fishes. Ultimately, there is a great sense of unity because all the principles and elements perfectly complement one another to express the general message: help save the Bluefin tuna. The advertisement is made by UNICEF to raise awareness about Bluefin tuna, a species that is threatened by extinction. This advertisement is intended for particular groups of audiences, namely, those who are not aware of the issue and those who have the capacity to contribute to the cause. The embedded text, saying â€Å"Would you care more if I was a Rhino†, suggests the lack of people’s awareness about Bluefin tuna. Well, we all know what tuna is. But most of us are not aware that there is a particular species of tuna that is endangered. The text certainly targets the emotion of the audiences by suggesting that these animals have been ignored for so long to the point of possible extinction. The text actually made the image more powerful and effective. It definitely carries the mark of UNICEF and further strengthens support for the cause. The primary goal of the advertisement is to introduce to the world the plight of Bluefin tuna, a species that is marginalized by people’s excessive emphasis on the survival of endangered animals on land, like the rhinoceros. The

High Pump Prices Oil Demand and Supply Factors Essay

High Pump Prices Oil Demand and Supply Factors - Essay Example The upward shift in the demand curve (D1 to D2) results from the increase in crude demand due to seasonal factors. As cited in the article, February is commonly slated for refinery maintenance. As such, decline in gasoline stockpiles occurs with refinery production slowing down. Ceteris paribus, a higher equilibrium point E2 is seen. The above graph also exhibits no shift in the supply curve S. This assumption is derived from the advisory of the Organization of Petroleum Exporting Countries (OPEC), a powerful cartel of major oil producers, that they would keep current output restrictions in place. In this regard, no additional supply may be expected to offset the increase in demand, thus, increasing crude price. Another case of supply and demand schedules interesting to analyze is the declining oil prices in the world market at the onset of 2007 (Ghatous 2007). Last year, oil price hovered at around $60-65 per barrel. With OPEC aiming to maximize its earnings, the cartel decided to reduce supply. However, oil price continued to slide despite the supply cut. This could be explained using Graph 2 below. Assuming an initial equilibrium price and quantity of $60 per barrel and 52 million barrels, respectively, an upward shift of the supply curve (from S1 to S2) due to the OPEC supply cut would cause an upward movement in the oil price. However, the supply shift was accompanied by a greater downward shift in the demand curve (from D1 to D2). The downtrend in demand resulted from the warmer than expected winter season in the US. With this, there is lesser demand for oil used for heating. Given the simultaneous shift in both supply and demand curves, equilibrium point E2 is reached with a lower price of $58 per barrel and quantity of 52 million barrels. References Articles Ghatous, G. (2007). "OPEC concerned about price, to act if needed". Reuters. Accessed: 14 March 2007 from http://www.reuters.com Valdmanis, R. (2007). "Oil rises on US fuel draw, eyes on OPEC". Reuters. Accessed: 14 March 2007 from http://www.reuters.com/article/hotStockNews/idUSSP28601520070314 Books Samuelson, P.A. and W.D. Nordhaus. (2001). Economics 17th Ed. McGraw-Hill. Sayre, J.E. and A.J. Morris. (2004). Principles of Microeconomics 4th Ed.

Cost of Capital Essay Example | Topics and Well Written Essays - 500 words - 3

Cost of Capital - Essay Example ls as far calculating the actual cost of capital of Pfizer, but it does point out that Pfizer has more equity than debt because the firms prefers to keep its interest payments low in order to maintain good liquidity and cash flows. Pfizer operates in industry that has very high risk. Every year hundreds of new medicines project fail for a variety of reasons. Sometimes these medicines do not work as the company expected or even when they work the new drug often is not able to comply with the strict protocols to achieve FDA approval. Whenever a medicine is not able to reach market the total costs that the pharmaceutical company incurred in becomes a sunk cost. A sunk cost can be defined as a cost that cannot be changed by any present or future decision (Weygandt, Kieso, Kimmel, 2002). Sunk cost are a major financial challenge for companies such as Pfizer. Minimizing projects that do not provide a positive stream of cash flows is imperative for the success of a company in the pharmaceut ical industry. Pfizer faces other financial challenges that are unique to its industry. For instance the company has to invest billions of dollars each year in research and development costs. The average out of pocket cost to develop a new drug is $1.4 billion (Mullin, 2014). Another financial challenge Pfizer faces is that it also takes a long time for a new drug to reach market. While a new drug is being developed the company does not obtain any inflows of cash from that project. Despite the challenges associated with developing a new drug when a company succeeds in creating a new product the law protects firms such as Pfizer. Patent protection allows Pfizer the ability to create a monopoly market on the new drug. Patent protection in the pharmaceutical industry can last eight to ten years. During that time Pfizer would face no competition for its new drug. Another challenge that Pfizer faces is a shortage of talent in many technical fields. In order to recruit new talent the firm

Technology research paper Essay Example | Topics and Well Written Essays - 1250 words

Technology research paper - Essay Example Some of the reasons include media intrusiveness and little added value that the Picturephone had over the normal telephones. Some articles report that the Picturephone failed to hit the markets positively because it lacked a robust reference point for its take-up. A majority of the successful new technologies have reference points, which are not extreme, for the society to get. Certain new technologies may seem disruptive but with societal reference point, these technologies are likely to be adopted by the society if they provide incremental improvements to the new users instead of comprehensive divergence from the normal life practices (Coburn 33)i. Prior surveys, before the Picturephone was launched, revealed that the market consumers were uncomfortable with the concept of being seen in the process of a telephone conversation. The Bell System defied the customers’ desires and wants proceeding to develop the new technology which was regarded as a solution seeking a problem. The Picturephone did not succeed because it failed to address the problems of the customers in the market, hence, customers did not have a reason to purchase and adopt the equipment (Brown 16). The Picturephones were installed in certain areas, such as Chicago and New York, in the United States in the 1960s and the cost of making telephone calls using these new technology equipment ranged between $16 and $27 for every minute used to make a call. Only 71 patrons had acquired the picturephones within the first half year of their development and marketing. Unfortunately, within a span of six years, the patrons of the Picturephones had declined to zero (Kaigo 3)ii. The use of Picturephones in making telephone calls was considered to be intrusive and crossed the privacy boundary of the users. The Picturephones did not improve the information on the voice but only made little advances on the communication. The flop of the technology

An analyss of The Four Seasons Hotel Guangzhou Essay

An analyss of The Four Seasons Hotel Guangzhou - Essay Example The Pearl River city is China’s economic pillar because it performs better economically in China. Ideally, this hotel’s location is a breathtaking cite as it offers a perfect view of the Pearl River Delta. The hotel also occupies the seventy-fourth to the ninety-eight floors totaling to almost thirty floors. Remarkably, the hotel boasts of having a twenty-four hour operational centre with executive club lounge facilities. With all these attributes in mind, the objective of this paper will be to analyze and evaluate the Strategic decision making for the Four Seasons Hotel. It will illustrate the design of the strategy, the implementation of the proposed strategy by factoring in the implications of the intended management change. Finally, it will evaluate the risks of the strategically choice and its performance. Various analysis models to ascertain the company’s current position 1. The PEST analysis The PEST analysis in business is the entails the Political, the E conomic, the Social, and the Technological factors that influence the external components of strategic management and market research (Griffin, 2010, p. 127). It helps a business to understand its market growth and potential in order for it to make advancements in its finances (Kayne, 2005, p. 227). Therefore, this part of the report will give explanations on the entire four components concerning Guangzhou Hotel. a) Political factor Essentially, the political factors refer to the level of government participation in its economy. These factors include taxes, labor laws, and trade regulations. In this case, China’s greatest political factor is being among the few remaining communist states in the world. China is a single party state in that property ownership is public. This is the fundamental rule in the communist form of leadership. This serves an advantage to the hotel since the chances of the hotel running bankrupt are relatively low. For instance, the government has the ri ght s to intervene in all financial aspects of the hotel enabling it to continue being the best performer in the hospitality market. Secondly, the Guangzhou Four Seasons hotel enjoys the government policy on taxation for foreign companies where they were to pay twenty-five percent income taxes (Brown, 2010, p. 16). The foreign company policy mentioned that they had to pay a twenty-five percent income. The fact that this tax implementation plan was gradual meant that Four Seasons hotel had adequate time to administer the government policy. b) Economic factors This is the second factor, which encompasses economic development, currency rates, and interest rates (Kayne, 2005, p. 231). The basic aspect of this factor is the ability to influence business functions and decision-making. As per this hotel’s setting, the economic factors crucially make them inevitable. In this regard, China’s economic growth dwindled in a scope of three years making the rates of investments bein g substantially low. This meant that the hospitality industry felt the strain, as there was little access to hotel facilities by both foreigners and locals. The business cycle dropped to a low of almost eight percent (BBC, 2012). The demands by the consumers decreased drastically as the main target for the Hotel were the foreign business guests who frequented the hotel. In addition, the exchange rate policy imposed by the government translated

Crisis Intervention with a Biblical Worldview Research Paper

Crisis Intervention with a Biblical Worldview - Research Paper Example There are different styles used under crisis intervention and among of them are screening/assessment from medical model and problem solving from alternate services. Crisis intervention is found to be a suitable management strategy for people with suicidal tendency (Berrino et al., 2011). It is also a proven effective strategy that can be applied in the midst and after of natural disasters (Bronisch et al., 2006). Crisis intervention is therefore a remarkable strategy that aims to restore the ability of an individual to adapt to its immediate environment and its adverse impacts. Crisis intervention therefore should require more encouraging words in the hope that it will help the individual understands the true meaning and value of life. People experience crisis in life when they are faced with obstacles to their important goals or are both faced with dangers and opportunities (James, 2008). Handling situation like this primarily requires important choices and encouraging words to rema rkably create better perspectives out of the problem. Jesus reminded us the importance of encouraging words and the value of our choices in life. He believed that people are more valuable than any other things on earth and nobody should worry on what to come in their lives because God certainly is able to provide everything for them (Luke 12:24). Thus, he simply tried to point out the fact that we are certainly not totally in control of ourselves but there is God who simply takes control over everything else. However, he also emphasized that each one has the choice to worry or not. Thus, effective counseling in crisis intervention is therefore a matter of effective participation of the concerned person. When an individual is not able to take control of his own self and his balance over everything is disrupted, crisis is doomed to come in his life (Dattilio and Freeman, 2007). This emphasizes the fact that the most important move to sustain him from his balance is an effective

Microsoft projecr Assignment Example | Topics and Well Written Essays - 750 words

Microsoft projecr - Assignment Example The first phase will deal with the design of the Customer Relationship Management System while the second phase will deal with the implementation of the system to the normal work flow environment. The design phase will incorporate various key features that will facilitate its efficient operation. The product that will arise from the project will be required to conduct tracking on the various trends of customer purchasing. The product is also to provide points to purchases that have been made cumulatively. The customers who have enrolled and registered into the system should therefore be able to redeem their points and receive various benefits. For the system to be able to produce the various deliverables, it is important that the Customer Relationship Management System be developed. It should also be complemented with a good intranet and extranet infrastructure that will allow synchronization of bonuses and loyalties from any outlet store. Apart from that, the software will need to work together with a Point Of Sale system which will be capturing the initial costs while the Customer Relationship Management System converts the prices to bonuses and royalty. The System will be developed and then introduced in the main branch to test. It will involve the installation of the system to computers which have the capabilities of running the software without any incompatibility issues. At the same time, a network infrastructure will be laid so that the whole company has a de-centralized system of operation with the main servers located at the head office. Shopping cards will be introduced where the bonus and loyalty points are stored. The system will also be installed in the other outlet chains to verify the synchrony of operations to the central server and test whether a customer’s points can be identified on any other retail store affiliated to the main store. Executive support – The management must support the system development process and the

Language spoken Essay Example for Free

Language spoken Essay England is filled with a mixture of different dialects and pronunciation. Every area or city has its own dialect pronunciation and specific words only used in that area for example in east London innit. The closer the areas are the more similar they are. In addition people living in a specific area have their own peer groups; these peer groups have their own sociolect. Sociolect basically, means language spoken by a social group, social class or subculture. In this regards it differs to the dialect of that area slightly. Every person in that peer group has their own idiolect. Idiolect means a variety of language unique to an individual. It is manifested when that person chooses the word phrases or idioms which are unique to an individual. The idiolect you speak is influenced by many factors, for example the area you live in, where you are from and who is in your peer group. These could happen simultaneously which will make your idiolect even more unique. I believe that your idiolect is mainly changed by your geographical location. My idiolect has been changed drastically through the years I have been living. Even though I was born in the UK the first language I was taught was Farsi, this was minor setback however I was able to overcome this issue. As I was sent to school, I renovated this issue and I was able to distinguish both languages and I usually never had to code switch. As I grew my knowledge on the English language increased considerably, however my amount of Farsi I knew increased at a really steady pace. This is because in school I was improving my English as it was a requirement at home this didnt happen a lot, my parents only wanted me to know the basics of my language and that was satisfactory for them. In addition my mum and dad wanted me to fit into society better. They done this by the process of primary socialisation, they told me not to swear, not to code switch so that I do not have to be deviant in school and to speak in standard English. At a very young age of 6-7 I was slightly getting confused with the English language. This is because as I spent time with my peer group they taught me their sociolect, at the time I wasnt educated on this topic enough. For example one day my friend told me when we were inside to Look out as there was a ball flying towards our window at a high speed. As I was not educated, I thought he literally meant for me to look outside luckily I did look outside but the ball missed me. This use of a phrasal verb confused me; this is because phrasal verbs also confuse non-native speakers and I wasnt that educated on this new type of dialect. At this time I started to mix both standard English and my sociolect until I reached 8 years old. At this time I was able to make out the type language I should use in school, the one I should use with my friends and the one I should use at home. Even though I was able to differentiate when to speak each language I still had problems. My English at this time was getting better day by day however my Farsi improvements came at a standstill. When I use to speak to my parents, and I could not find the correct term in Farsi, I had to say it in English. This caused me to code switch even more. This automatically made me speak a mixture of English and Farsi when I went home. Did not finish (deliberate), Mrs Hart please tell me what I should add to improve; what I can to make it even better. I was going to talk about my transcript however I am unable as I want to know the mistakes I have made so that I can make it better with the transcript By Wariss Tamim 10. 8.

Comparison of Positivist and Phenomenological Methods

Comparison of Positivist and Phenomenological Methods Describe, compare, contrast, and critically evaluate the effectiveness of both positivist and phenomenological methodology adopted when studying society. Sociology is the study of human society, including both social action and organisation. Sociologists use scientific research methods and theories, and study social life in a wide variety of settings, this offers not only information but also a distinctive way of looking at the world and the position humans play in it. Whereas most people try to explain events by analyzing the motives of those involved, sociologists encourage a look beyond individual psychology to many recurring attitudes, actions and how these patterns vary across time, cultures and social groups. To look at the different ways people act and behave in society, it has to be seen from a sociological perspective. Within sociology there is no single method, but many. As stated by Haralambos and Holborn (1995) Science appeared to be capable of producing objective knowledge that could be used to solve human problems and increase human productive capacity in an unprecedented way. This assignment will look at the two main me thodologies, used by sociologists, past and present, and compare the effectiveness of the two. When the task of comparing and contrasting the two methodologies of positivism and phenomenology, adopted within the study of society, there are many things that leap to mind: Firstly, there is the factor of time or circa and secondly is the influence of certain acclaimed sociologists within the two different approaches. Methodology within sociology is the study of methods and deals with the philosophical assumptions underlying the research process, using scientific quantitative data collection under those philosophical assumptions. The broad methodology positions, positivism and phenomenology differ hugely. Positivism contains the underlying philosophical assumptions of research in the most pure and applied sciences, physics, chemistry and biology, based on ideas of the objective reality of the physical world, scientific method and empiricism. Just as positivism arose out of rejecting speculation an alternative view has arisen out of rejecting the view that scientific empiricism can be applied to the social world. There is no one philosophical basis, but phenomenology, which can be seen as the basis for what is the assumption that society can only really be understood through personal actions such as language, feelings and emotions. As stated by Kirby, Kidd, Koubel, Barter, Hope, Kirton, Madry, Manning and Triggs, (2000), that although not perfect the link between the methodologies is that the structuralist-minded sociologists tended to adopt a positivist approach and social action based sociologists tend to adopt a phenomenological approach. The positivist versus the phenomenological approach to the study of man and society is considered in terms of one of the major debates in social science research. Many of the founding fathers of sociology such as Marx (1818-1883), Comte (1798-1857) and Durkheim (1858-1917) believed that it would be possible to create a science of society based on the same principles and procedures as natural sciences. Positivist theorists believed that this approach would reveal that the evolution of society followed invariable laws and that it would show that the behaviour of man was governed by principles of cause and effect which are just as invariable as the subject of natural sciences. Kirby et al, (2000) states that positivists believe that only by adopting a position of total objectivity towards the subject matter or phenomena can unbiased knowledge or theories be produced. Comte believed in the hierarchy of science and that each study of science is dependent upon another. His theory ranged from the simplest to the more complex forms of science and that sciences above rely on sciences below stating that sociology was more abstract and difficult than other sciences. Originating from his hierarchy of science, as stated in Haralambos and Holborn, (2004), Comte widely believed that industrialization and the growth of scientific knowledge would lead to secularization, therefore devising his contribution to the study of social dynamics in that, the rule of societies passing through three stages defined by their social relationships. Theological law was a belief in superhuman or divine powers, Metaphysical, a belief in the powers of the individual human mind and the positive law was based on truth produced by collaborative, quantitative and scientific work. An appeal of the positivist approach is that scientific knowledge does not contradict or surprise the ex perience of the everyday world. It argues that factors, which are not directly observable, such as meanings feelings and purposes, are not particularly important and can be misleading, they therefore, form, reliable quantitative data. Phenomenological theorists such as Simmel (1858-1918) and Weber (1864-1920) propose that the consciousness is the proper area of study, for its study will reveal meaning. They seek to sense reality and describe in words rather than numbers, trying to produce convincing descriptions of what they experience rather than explanations and causes. Weber disagreed with Comtes theory, he believed there could be as many sciences as needed, Quantitative and empirical studies cannot tell people what to do, and it is important to go beyond simply recording events and to explain the reasons behind them. When referring to Webers idea of puritanism, a case study in the empirical construction of the protestant ethic, Weber, as cited by Ghosh (2003), clearly states that empirical sources are not tablets of stone, eternally available to the truth seeking historian; rather they have a history of their own. Weber believed that values play a crucial role before during and after research and that social a ction is governed by the dynamic of individual needs. Weber was committed to the study of causality, the probability that an event would be followed by another event not necessarily of a similar nature. In addition to this Weber also analysed the levels to which rationality was becoming institutionally embedded in modern industrialised societies. Marxs view of bureaucracy was according to Weber a form of organisation superior to all others, Weber wrote in one of his many books, that without this form of social technology the industrialised countries could not have reached the wealth and extravagance that they currently enjoy, (Weber, 1928) as cited in Haralambos and Holborn, (2004). He believed that this capacity for social order would lead to the evolution of the iron cage, and as a result, a society that was technically ordered, rigid and dehumanized. As stated by Giddens (1997) Weber sought to understand social change. He was influenced by Marx but was also strongly critical of s ome of Marxs major views, rejected the materialistic conception of history and saw class conflict as less significant than Marx. From a positivist stance, Marx believed that ideas were expressions of public interest and that they served as weapons in the struggle between classes and political parties. Class for Marx, is defined as a social relationship rather than a position or rank in society. Class struggle and owners of production determined economic order. In Marxs view, classes are defined and structured by work, labour, possessions, production, and the class structures of capitalism consisted of class struggle, political power and the development of a classless society. Marxs theory of society consisted of two categories of class and that economic order was determined by the two; Bourgeoisie, the capitalist class, the hierarchy, the wealthy, the employers and the Proletariat, who are the workers or the lower class. His view was that as the bourgeoisie employed the proletariat, who has to fulfill his basic needs, the capitalist class could not exist without them. As cited by Haralambos and Holborn (1995), Marxism has sometimes been regarded as a positivist approach since it can be argued that it sees human behaviour as a reaction to the stimulus of the economic infrastructure. Although Weber agreed with Marx in part, that as methods of the organisation increased efficiency and effectiveness of production, Marxs theory threatened to dehumanise society. Webers theories, stratification and views on economic behaviour were rooted from Marxs view on the economics of a society. Another positivist view came from Emile Durkheim, whose impression of society was of structures that function apart from human purpose and will. While he considered society to be composed of individuals, his theory was that it is not individuals behaviours, thoughts and actions that construct society, but that society has a structure and existence of its own. His thought was, that society was to have developed from traditional to modern society, through the expansion and development of the division of labour, of course, it is individuals who act, but they do not act on a purely individual basis, they have obligations and duties and are strongly influenced by structure, tradition and the roles of our forefathers. Durkheim considered himself with the issue of social order and how modern society holds together, given that society is composed of many individuals each acting in an individual and autonomous manner. Durkheims classic study of suicide, (1970, first published in 1897), as cit ed in Haralambos and Holborn, (2004) is often seen as a model of positivist research and it does indeed follow many of the methodological procedures of positivism. Although supporting the two different methodologies of sociology, Durkheim was heavily influenced by Weber, who defined sociology as the study of social action between individuals. In contrast to Durkheims impression of society and view that society has an existence of its own apart from the individuals in it and so proceeds a proper object of study. As argued by Haralambos and Holborn (1995) where Marx was pessimistic about the division of labour in society, Durkheim was cautiously optimistic. Marx saw the specialised divisions of labour trapping workers in their occupational role, Durkheim saw problems arising from specialisation in industrial society, but believed the promise of the division of labour far outweighed the problems. While Simmel is generally not regarded as being as influential in sociology as were Marx, Weber and Durkheim, Simmels theories, had some similarities to Durkheims theory of problems of individuality and society, Webers dynamic of individual interests and Marxs theory of class structure. Simmel considered society to be an association of free individuals and that society could not be studied in the same way as the physical world for example, sociology is more than the discovery of natural laws that govern human interaction. His theory was that society is made up of the interactions between and among individuals and that, sociologists should study the patterns and forms of these associations rather that look for social laws. By defining sociology in this way, Simmel avoids the conflict about the nature of science whether it should be concerned with timeless, universal laws, instead, there are always multiple ways in which we can look at things. He argued that society was made up of soc ial facts, and these social facts coerce and shape the actions of individuals. He argued that in traditional societies, solidarity binds together individuals in order to allow society to operate. Social facts only come into being in an interaction, and do not exist within an individual consciousness. Durkheim (1970) as cited in Haralambos and Holborn (2004), stated that the determining cause of a social fact should be sought among the social facts preceding it and not among the states of individual consciousness, the causes of variations in suicide rates were to be found in social facts and in society rather than the individual. Therefore, social groups represent. He argued that societies that functioned well were societies that held a consensus sway over individuals; society, therefore, was something outside and inside individuals. As stated by Haralambos and Holborn (1995) to phenomenology, it is impossible to measure objectively any aspect of human behaviour, through language humans distinguish between different types of events, actions, objects and people. The process of categorisation is subjective; it depends upon the opinions of the observer. Statistics are simply the product of the opinions of those who produce them. The distinction between positivist and phenomenological approaches is not as clear-cut as this assignment implies. There is a considerable debate over whether or not a particular theory should be labelled positivist or phenomenological. Often many of the theorists lie somewhere in between, some taking views from either side. Haralambos and Holborn (1995) argue that in terms of sociology, the positivist approach makes the following assumptions; the behaviour of humans, like the behaviour of matter, can be objectively measured, just as the behaviour of matter can be quantified by measures such as weight, temperature and pressure. Methods of objective measurement can be devised for human behaviour, such measurement is essential to explain behaviour. Early Positivists such as Comte, and Durkheim argued that objectivity was attainable by adopting a scientific methodology. Marx also believed that his sociology was objective and scientific, although he saw society very differently. Weber did not think complete value freedom was possible, but he did believe that once a topic for research had been chosen, the researcher could be objective. He argued that sociologists should not make value judgments, that is, they should not state what aspects of society they found desirable or undesirable. It is plainly nonsensical to throw into one big pot labelled sociology all those researches which could have been satisfactorily conducted by national economy, history of civilisation, philosophy, political science, statistics, demography and ethics. That gives us a new name, but no new knowledge. Simmel, G (1858), cited in American Journal of Sociology [online]) (1898) Reference List Ghosh, P, (2003), Max Webers Idea of Puritanism: A Case Study In The Empirical Construction Of The Protestant Ethic, History of European Ideas, [online], 29;2, 183-221, Available at: http://www.sciencedirect.com/science?_ob=ArticleURL_udi=B6V9C-48D2RD7-1_user=10_rdoc=1_fmt=_orig=search_sort=dview=c_acct=C000050221_version=1_urlVersion=0_userid=10md5=10803212fe05d9a06d9a7ce5cfaec919 [Accessed November 21, 2008] Giddens, A, (1997) Sociology, 3rd Edition, Polity Press, Cambridge Haralambos, M, Holborn, M, (1995), Sociology, Themes and Perspectives, 4th Edition, Collins Educational, London Haralambos, M, Holborn, M, (2004), Sociology, Themes and Perspectives, 6th Edition, Collins Educational, London Kirby, M, Kidd, W, Koubel, F, Barter, J, Hope, T, Kirton, A, Madry, N, Manning, P, Triggs, K, (2000), Sociology in Perspective, Heinemann Educational, Oxford Simmel, G (1898) The Persistence of Social Groups, American Journal of Sociology, [online], 5; 3, 662-663. Available at: http://www.brocku.ca/MeadProject/Simmel/Simmel_1897a.html [Accessed November 11th 2008]

Polycystic Kidney Disease Causes and Treatment

Polycystic Kidney Disease Causes and Treatment   Introduction: Polycystic kidney disease effects roughly 10 million people worldwide. Even though this disease is so prominent it lacks research in the field of therapeutics from biopharmaceutical companies as they invest their resources into fields which are seen to be more profitable i.e. cancer research. This lack of research is what enticed us to carry out our project on polycystic kidney disease. This project will firstly outline the history of the polycystic kidney disease, how it effects patients, the cause of the disease and the current therapeutic treatment available to combat polycystic kidney disease in section 1. Section 2 will look at the current diagnostic methods employed by a physician to see if a patient is suffering from polycystic kidney disease. Diagnostic methods such as imaging and genetic testing will be dealt with here. Lastly section 3 will look at a potential new diagnostic technique which has been formed using proteomic techniques to identify the difference between a healthy polycystin-1 protein compared to a mutated polycystin-1 protein. The first record of Polycystic Kidney Disease (PKD) is from the 16th century. In 1586, the King of Poland died from cysts on his kidneys. The cysts were described by his surgeon as large like those of a bull, with an uneven and bumpy surface. At the time of his death he was diagnosed with meningeal abscesses. It wasnt until a group of physicians re-examined the records of the Kings death over 300 hundred years later that his cause of death was agreed to be PKD. The term polycystic kidney disease was first used by Fà ©lix Lejars in 1888, although the mode of inheritance of this disease wasnt understood for almost another one hundred years. In the 1990s, the formation of cysts was understood at a molecular level. This helped in the discovery of the genes that cause PKD (Ayse, 2016). Figure.1 A visual representation of the transmembrane proteins Polycystin-1 and Polycystin-2. Also seen is the Polycystin-1 receptor located in extracellularly. (Gallagher, Germino and Somlo, 2010) PKD is a genetic disease in which the renal tissue within the outer cortex and inner medulla is replaced with fluid filled sacs (or cysts). These cysts enlarge the kidneys and inhibit kidney function. Hypertension, hematuria and chronic pain are the most common symptoms associated with PKD (Seeger-Nukpezah et al., 2015). PKD has two forms; Autosomal Dominant (ADPKD) and Autosomal Recessive (ARPKD). ADPKD is the result of the inheritance of one mutant PKD1 or PKD2 gene, which affects ~1:750 people worldwide. 85% of ADPKD cases are caused by mutations in PKD1. Mutations in this gene lead to earlier disease onset. The other 15% of cases are attributed to a mutation in PKD2. All ADPKD patients inherit one normal allele and one mutant allele. Cases where both alleles have the dominant mutation lead to embryonic lethality. ARPKD is caused by the inheritance of two recessive mutated PKHD1 genes. ARPKD is considerably less common with an incidence of 1:20,000. ARPKD progresses at a much faster rate than ADPKD. It usually causes death at birth or requires transplantation in early childhood. Multiple different types of mutations in PKD1, PKD2, and PKHD1 have been researched, including frameshifts, deletions, and premature stop codon insertions (Wilson, 2015). In the dominant form of PKD there is only one mutated gene inherited. This mutated gene is unable to produce the proteins PC-1 or PC-2. However, the non-mutated allele can still function as normal and can produce enough of the polycystin proteins to maintain kidney function. It is only when a somatic mutation occurs causing the normal allele to become inactivated that symptoms of the disease will occur. (Torres and Harris, 2010) PKD-1 is located on the short arm of chromosome 16 (16p13.3). PKD-2 gene is located on the long arm of chromosome 4 (4q21) (Nowak et al., 2016). Polycystin-1 and 2 are large transmembrane proteins which are encoded by PKD1 and 2. Both proteins affect multiple downstream signalling proteins (Seeger-Nukpezah et al., 2015). In a normally functioning nephron as the urinary filtrate flows by and causes the primary cilia to bend polycystin 1 and 2 respond by allowing calcium influx which activate pathways in the cell which inhibit cell proliferation. PC1 has the ability to sense when the primary cilia bends which activates PC2 calcium channels. If either PC1 or PC2 is absent the signal to inhibit cell growth is not received (Chebib et al., 2015). PKD1 or PKD2 mutations cause a reduction in intracellular calcium. This triggers a change in the response of the cell to cyclic adenosine monophosphate (cAMP) from suppression to proliferation. The concentration of cAMP directly affects the activity of Protein Kinase A. Four cAMP molecules are required to activate one PKA enzyme. The increased production of cAMP via adenylyl cyclase 6 is dependent on vasopressin (Chebib et al., 2015). Despite the many breakthroughs in research allowing for a greater understanding of the disease, there is currently no cure for PKD. However, there are drugs which can suppress symptoms brought on by the disease. Beta blockers such as, Tenormin, can be used to treat hypertension and haematuria can be treated with antibiotics. Understanding the effect of PC1 and PC2 mutations on the vasopressin receptor in the cell lead to the development of Tolvaptan. This drug slows down the formation of cysts in the kidneys. Tolvaptan blocks the vasopressin receptor, which will stop the signalling pathway. Therefore, cAMP production will be reduced. (Ema.europa.eu, 2017) The current diagnostic methods for polycystic kidney disease include genetic testing, pre-natal testing and imaging studies in the form of ultrasounds, CT (Computed Tomography) scans and MRI (Magnetic Resonance Imaging) scans The imaging studies take a scan of the kidneys to identify the presence of any abnormalities in the form of renal cysts. An ultrasound mechanism uses high frequency sound waves to capture and visualise images that cant be seen with the naked eye. The CT scan combines many x-ray images with the aid of a computer to generate cross sectional views and/or three-dimensional images of the kidneys and the MRI scan uses a magnetic field and pulses of radio wave energy to from pictures of the kidneys. The appearance of three or more renal cysts, either unilateral or bilateral, on the image is enough to diagnose a patient between the ages of 15 and 39 with polycystic kidney disease. In patients aged 40 59, the presence of two or more cysts in each kidney fulfils the criteria to diagnose the patient with polycystic kidney disease. The presence of four or more cysts in each kidney is used to diagnose older patients (F. Belibi et al., 2008). The kidneys on an image may appear enlarged but retain their normal reniform shape in the case of a patient presenting with possible polycystic kidney disease. The medullary pyramids in the centre of the kidney may be more visible on an image in contrast to the cortex which can give a peripheral halo on the image obtained. High resolution imaging studies allows the visualisation of numerous cylindrical cysts within the medulla and the cortex which represent ectatic collecting ducts within the kidney (F. Gaillard, 2015). Genetic testing for polycystic kidney disease is for those who have a family history of polycystic kidney disease who has no symptoms and may consider being screened for the disease. Genetic tests can be done to screen for both PKD1 or PKD2 mutations. A method of PCR known as PCR- SSCP (Polymerase Chain Reaction Single Strand Conformation Polymorphism) is used to view mutations, if any, in the patients genomic DNA. In SSCP analysis, a mutated DNA sequence is detected as a change of mobility in polyacrylamide gel electrophoresis caused by the altered folded structure of single-stranded DNA (K. Hayashi, 1991). The genomic DNA of the white blood cells in patients with the possible polycystic kidney disease gene are isolated. These samples of genomic DNA are then amplified by PCR using two primers to amplify the potential polycystic kidney disease genes (R. Jas et al., 2012) The PCR product is then analysed using the SSCP method. This method involves loading the PCR product samples onto the acryl amide gel and gel electrophoresis occurs. After completion of the gel electrophoresis step, the gel is subjected to silver staining to visualise the SSCP band patterns (B. Yadav et al., 2009). The silver stained gel is kept on a transilluminator and the SSCP variants are recorded. DNA samples from the abnormal bands seen on the transilluminator are sequenced to see what kind of mutation and where the location of the mutation is on the polycystic kidney disease gene (Z. Dian-Yong et al., 2002). In PCR-SSCP analysis, changes in several hundred base pairs are detected in contrast with other techniques in which changes in relatively short sequences can be detected. Because of this, PCR-SSCP analysis is much more sensitive to the replication errors that can occur during the PCR process (K. Hayashi, 1991). Diagnosis of polycystic kidney disease can also be done prenatally. If the parents agree, a prenatal diagnosis can be done on the developing fetus if there is a history of polycystic kidney disease in either the parents or extended family . A DNA sample is taken from both parents and a sample of tissue is taken from the fetus. The tissue sample is obtained from the fetus by a procedure called aminocentesis which involves passing a needle into the mothers lower abdomen and into the amniotic cavity inside the uterus. The sample is then amplified by PCR to detect any mutations in the DNA that could lead to the fetus developing polycystic kidney disease in the future (K. MacDermot et al., 1998). The imaging studies, genetic testing and prenatal testing for polycystic kidney disease have advantages and disadvantages. One advantage of the imaging studies is that they are reliable, inexpensive and a non-invasive way to diagnose polycystic kidney disease (A.Khan, 2015). A disadvantage of imaging studies is that while they are sensitive in the detection of polycystic kidney disease, problems may arise with smaller cysts. Smaller cysts on scans may not be easily differentiated from small, solid masses within the kidneys (A.Khan, 2015). An advantage of CT scans when compared to MRI scans is that the cysts on the kidney will enhance on the image when dye is administered into the patient intravenously (A. Khan, 2015) (F. Gaillard, 2015). MRI scans of the kidneys are becoming a useful technique in diagnosing more complicated cysts and can be used in addition to or instead of CT scans (A. Khan, 2015). The advantage of genetic testing as a method of diagnosing polycystic kidney disease is that it can determine if a person who has a relative with polycystic kidney disease will in the future start showing symptoms of the disease. Some disadvantages of genetic testing as a method of diagnosing polycystic kidney disease is that they are extremely costly tests to carry out and sometimes they cant pick up on certain gene mutations that could eventually lead to the person having polycystic kidney disease (National Kidney Foundation, 2016). The major advantage of prenatal testing for polycystic kidney disease is the fact that treatment using cyst suppressing drugs can be used early in the diseased patients life meaning the formation of renal damaging cysts will be slowed down drastically compared to a patient who was not on the cyst supressing treatment early in their life time. The negative of prenatal testing is of course the invasive nature of extracting tissue from the foetus which many parents would not agree with however the benefits of early diagnosis of this disease will lead to a better quality of life for the child in their later years. As discussed in the previous section the current diagnostic methods for diagnosing polycystic kidney disease is through the use of various scans and genetic testing. The genetic testing is carried out by analysing the DNA sequence in order to identify any mutations which may be present. As a new method of diagnosing this disease a study of the protein polycystin-1 which when mutated is responsible for polycystic kidney disease, will be analysed by using proteomic methods. Firstly, the polycystin-1 protein must be extracted from a patient who wishes to obtain diagnosis of the disease. Since polycystin-1 is a membrane protein and is located in the kidney it will be necessary to extract kidney tissue from the patient by carrying out a quick and simple biopsy procedure. The biopsy removes kidney tissue by inserting a thin biopsy needle through the skin and into the kidney whilst the patient is under local anaesthetic. Now that tissue containing the polycystin-1 or its mutated form is extracted from the patient it must be treated in order to release the proteins contained within the tissue. The tissue will firstly be homogenized and lysed in order to release the proteins into solution. The sample will then be centrifuged at 14,000 rpm at 4ÃÅ'Ã…  C for 15 min. This centrifugation step removes any insoluble material and the supernatant will contain the proteins from the tissue sample including the protein of interest polycystin-1. This method was carried out by Malhas, Abuknesha, and Price 2001 whilst trying to crystalize the polycystin-1 protein. Now that polycystin-1 is in solution it can be separated from the other proteins by means of 2D gel electrophoresis. This technique will separate the polycystin-1 protein from other proteins based firstly on their isoelectric points (pIs) and secondly by their molecular weight. After carrying out this two-dimensional separation the gel is stained with stains such as coomassie brilliant blue (CBB) or silver staining in order to visualize the spots on the gel. By carrying out bioinformatical analysis the molecular weight and pI of polycystin-1 can easily be obtained (Mishra 2010). The molecular weight of polycystin-1 is 460.3 kDa and it has a pI of 6.27. With this information, the band which corresponds to the molecular weight and pI of polycystin-1 can be easily identified and excised from the gel. Before excising the polycystin-1 protein from the gel it must first be fragmented into peptides using trypsin cleavage. By fragmenting the protein with trypsin, peptide molecules are formed which are now suitable to be sequenced using MALDI-TOF mass spectrometry. These peptides must then be suspended in a matrix suitable for MALDI-TOF MS. An example of such a matrix is ÃŽÂ ±-cyano-4-hydroxycinnamic acid which was used in the work carried out by Malhas, Abuknesha, and Price, when they crystallized the polycystin-1 protein using the MALDI-TOF technique. This matrix is suitable as the peptides are below 5 kDa. The matrix and peptide mixture is then loaded onto the metal plate of the MALDI-TOF MS analyser where it will be hit by a pulsing UV laser. The matrix molecules absorb the UV light causing the matrix molecules to enter the gas phase along with their coupled vaporised peptides which then become ionized. The TOF MS then measures the time it takes the ions to fly as lighter ions travel faster. The ions will then hit the ion detector and the on board computer will produce the plot of the mass spectrum (Kraj and Silberring 2008). MALDI-TOF MS is the ideal method to analyse the polycystin-1 protein as like ESI, it is a soft ionization technique meaning there will be little or no fragmentation of the compounds being analysed. Once the mass spectrum is obtained it is then compared to the mass spectrum of the normally functioning polycystin-1 protein which can theoretically be fragmented by trypsin in the online databases. Any differences between the sample and the known mass spectrum of the normal protein will signal a mutation has occurred. This method of protein analysis is a very effective and efficient way of screening for the mutated proteins. The study carried out by Brioude et al 2016 proves this as they looked at using MALDI-TOF MS to test for mutated proteins leading to lung tumours. In this study, they concluded that the method is very promising and it should be used in several surgical settings where rapid evaluation of abnormal tissue is required. This highlights how this new method of analysing polycystin-1 for a mutation could prove very effective in diagnosing polycystic kidney disease. This method holds a distinct advantage over the imaging methods currently in use as diagnosis can be made early in a patients life before they show symptoms or the formation of cyst on their kidneys which are associated with polycystic kidney disease. Early diagnosis of this disease means that drugs for the prevention of cyst formation such as Jinarc © which contains the API Tolvaptan can prolong a patients kidney function by slowing down the rate at which the fluid filled cysts on the kidneys are formed. This method is used to identify a mutation of the polycystin-1 protein which attributes to 85% of autosomal dominant polycystic kidney disease cases. The other 15% is made up of mutations of the protein polycystin-2. Fibrocystin is the mutated protein responsible for autosomal recessive polycystic kidney disease. Both the dominant and recessive forms of this disease can be diagnosed using the above method in order to identify a mutation in either polycystin-2 or fibrocystin proteins if there is no mutation of polycystin-1 observed. From the above sections, it can be seen how sever and prominent polycystic kidney disease is worldwide. Although this disease is genetically inherited from or both parents, symptoms of the disease are slow progressing. In 85% of cases the disease will not advance to renal failure until the patient is 50-60 years of age. The current diagnostic techniques currently used by doctors such as imaging and genetic testing have their benefits however they are also flawed. The major disadvantage seen in this project regarding the current diagnostic techniques is the diagnosis of polycystic kidney disease in a patient where uncontrolled cyst formation has already occurred and serious renal problems have begun. With the use of our new proteomic technique earlier diagnosis will be possible before the disease has progressed to renal failure. Early diagnosis means that the use of drugs such as Tolvaptan © can be used to significantly slow down cyst formation which will ultimately increase the length of time a patient suffering with polycystic kidney disease has before renal failure occurs. 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Rusni Mohd, Jas (2012) Amplification of Real Time High Resolution Melting Analysis PCR Method for Polycystic Kidney Disease (PKD) Gene Mutations in Autosomal Dominant Polycystic Kidney Disease Patients African Journal of Biotechnology, 11(25). Seeger-Nukpezah, T., Geynisman, D., Nikonova, A., Benzing, T. and Golemis, E. (2015). The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nature Reviews Nephrology, 11(9), pp.515-534. Torres, V. and Harris, P. (2010). Comprehensive Clinical Nephrology. 4th ed. Elsevier Saunders, pp.529-542. Wilson, P. (2015). Therapeutic targets for polycystic kidney disease. Expert Opinion on Therapeutic Targets, 20(1), pp.35-45. Z. Dian-Yong, Z. Shu-Zhong, T. Bing, Z. Wei-Li, D. Bing, S. Mao, S. Tian-Mei M. Chang-Lin (2002) Detection of Polycystic Kidney Disease Gene 2 Mutations in the Hans by PCR-SSCP Academic Journal of Second Military Medical University, 01 (1).

Essay --

Bill the Butcher, a nativist man, willing to kill and die for his own country. Dislike Irish immigrants, and African Americans, an egocentric man. Bonnie and Clyde a couple who met young, committed their crimes together, and ultimately died together. These notorious characters from history have formed a platform of violence among those around them. Bill the Butcher, and Bonnie and Clyde, their thoughts, their views, and their lives; alike and different at the same time for government/ authority, power, their crimes, their atmosphere ( events surrounding them ), and ultimately their deaths. Bill the Butcher's view on government was that the natives basically run everything. He has a big dislike for irish immigrants coming into the U.S. In the film Gangs of New York Bill the Butcher finds the Irish as a waste of space, of no use, and unwilling to die for the Nations that has opened their doors to them. He is egocentric believing that Natives are superior to any others residing the area, including African Americans. Bonnie and Clyde in ‘’ The Lives and Times of Bonnie and Clyde’’ do not present an actual hate toward government, rather as Milner shows, a sense of rebellious criminals, ‘’ They call them cold blooded killers’’ ( ). The title of the chapter impling who they are, not just thieves, and burglars, but murders. Bill the Butcher was willing in his eyes kill and die for his country, Bonnie and Clyde on the other side, were destroying the government with their crimes, leading officials to investigations, and chase s after the two. Bill the Butcher presents a sense of power in his character, he is the leader of a Nativist gang as Asbury states called the (----) (Page). In the book Bill the Butcher is known as Asbury states ... ... sense of rebellion, and standing your ground, Bill the Butcher not liking the Irish immigrants, even when the government was allowing them to come in; Bonnie and Clyde not settling to live like others in poverty, and if times were hard, well they made times hard for those who were doing well, public officials..''the law..'' (PAGE). Blibliography Asbury, Herbert. The Gangs of New York. Leicester: W.F. Howes, 2003. Print. Milner, E. R. The Lives and times of Bonnie and Clyde. Carbondale: Southern Illinois UP, 1996. Print. Gangs of New York. Dir. Martin Scorsese. Perf. Daniel Day- Lewis, Cameron Diaz, Leonardo Decaprio. Twentieth Century Fox, 2003. DVD. Bonnie and Clyde : Dead and Alive. Dir. Bruce Beresford. Perf. Emile Hirsch , Holliday Grainger. Sony Pictres Television, 2013. Televison Program Movie.

All The King’s Men :: essays research papers

The title of the book is All The King’s Men and the Publication date for this book is 1996. The author Robert Penn Warren was a very famous author. His life was full of many achievements that helped him become recognized. He even won the Pulitzer Prize for this book All The King’s Men. Warren was inspired to write this book because when he was younger he lived in the state of Louisiana and around this time Huey P. Long was already an established politician. Warren started out writing poetry but then turned to writing novels. His works are loved and cherished by many and even used in today’s schools. It is safe to say that Robert Penn Warren was one of America’s most brilliant writers. This book takes place in the southern part of the United States in the 1930s. Although Warren never reveals the true setting of this book, one can conclude that this took place in Louisiana seeing how Warren became inspired in that state by a person who is mirrored in this very book. Part of this novel is in Mason City. Another place in this novel is Burden’s Landing Jack , the main character, goes there many times because this is his hometown. This novel is mainly about the rise and fall of the political figure Willie Stark told through the eyes of his business associate and friend Jack Burden. Willie stark in his early political career is all for helping the people and trying to do what is best for them. As he gains power and the trust of his people he soon becomes corrupt by the evils of success. Characters Jack Burden- He is the narrator of this story and he is the companion of Willie Stark. He works at a newspaper company before getting a job from Willie after they become acquainted . Readers will learn his story while they are learning about the life of Willie. Willie Stark-He becomes a treasurer of Mason City and from there his political career takes flight. After becoming a treasurer Stark decides to study law and become a lawyer. After he receives some success he runs for governor and becomes a power-hungry politician. Sadie Burke-She was an employee and mistress of Willie Stark. She has a crude behavior and has an outspoken personality. Later she becomes very intolerant in all the women Stark is with. Two reoccurring motifs and symbols are The Great Sleep and the Hospital.

Dylan Thomas :: essays research papers fc

  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Dylan Thomas combines his vibrant imagery with his adolescent experiences in South Whales and London to produce the realistic tale â€Å"The Followers†. His interest in writing short stories like â€Å"The Followers† stems from the beginning part of his life.   Ã‚  Ã‚  Ã‚  Ã‚  Thomas spent his days growing up in Swansea, South Whales with his father, a grammar school English teacher. His father encouraged his early interest in reading and writing. Some of his early poetry was published in local literary writing journals. Thomas grew up in the late 1920’s and the 1930’s. â€Å"In the 1930’s, when the trend toward social and political commentary dominated the arts, Thomas began pursuing more personal themes that originated in his own experiences† (Gunton and Harris 358). Thomas would then incorporate these experiences into his poetry. For example, the poem â€Å"The Ballad of the Long-Legged Bait† is about a fisherman he probably saw around growing up in Swansea. In 1934 Thomas began moving between London and several villages where he started drinking a lot and â€Å"epitomized the raucous image of an artist† After WW II, Thomas began writing more short stories rather than poetry (Gunton and Harri s 358).   Ã‚  Ã‚  Ã‚  Ã‚  Much earlier stories focus on a theme of either birth or death. Because of this, Thomas’s early period has been called his â€Å"womb-tomb† era (Gunton and Harris 358). As Thomas’s writing style evolved, he would begin to experiment with new techniques. He started using vibrant images and using sound as â€Å"verbal music†, creating his own poetic style (Gunton and Harris 358). However, many times Thomas will try to convey emotions that are too complex for any lyrical treatment. Other times the opposite can be true and he gives too intricate an elaboration to simple feelings (Olsen 366). These elements of Thomas’ style are evident in his poems and stories, such as â€Å"The Followers†.   Ã‚  Ã‚  Ã‚  Ã‚  The roster of characters in â€Å"The Followers† are the unnamed narrator, his good pal Leslie, and a girl whom they call â€Å"Hermoitte Weatherby†. The narrator and Leslie meet in a pub on a rainy, London night. They leave after a while, due to lack of funds and decide to have a spot of fun by following a girl they don’t know (Hermoitte) to her home. They spend the evening watching â€Å"Hermoitte† and her mom doing a lot of nothing they are discovered by them and a third unknown voice inside. They flee their window perch in a hurry and call it a night.

Week 5 Reflection

Week Five Reflection Paper Team B will reflect on why it is important for management as well as investors and creditors to understand the current and long-term liabilities. What makes it important to disclose contingencies as well as how do operating and capital leases relate to liabilities. It is important for managers to know what the company has as current or long-term liabilities because if they are not aware of what the funds look like they cannot affectively run the company. This knowledge helps a manager be more effective at planning and organizing what the companies priority are.Without taking time to learn this, managers could overdraft a company’s bank account just trying to order supplies. External vendors would want to obtain this kind of information for a few reasons. One, investors who want to invest in your company they want to make sure they are making a very sound decision on their investment. Investors would not invest in a company if it was on the verge of f iling for bankruptcy or going out of business. Creditor will also look at a company’s current and long-term liabilities.If a business has too much or too little debit this could be a sign of not being stable. So for a creditor this would also a high risk if they did not take the time to do some research and crunching of the numbers to see where the business or individual stands. The importance of disclosing any contingencies is really to keep companies honest about how their business is doing. Per FASB disclosing of this information gives financial statement users the ability to understand the nature of a loss contingency, potential magnitude as well as if known the potential timing.With a capital lease the liability relation would be equal, as you would list this lease on all financial statements, balance sheet, income statement as well as the cash flow statement. With operating leases the effect would be listed on the income statement and the cash flow statement but not the balance sheet. So team B has briefly reflected on the understanding of current and long-term liabilities, why is it important to disclose contingencies as well as how does operating and capital leases related to liabilities.

Pierre Bourdieu

Pierre Bourdieu (19302002), Professor of Sociology at the College de France, might come into beguile an incredible fuckdidate for inclusion under the championship of connoisseural system. An erstwhile structuralist, whose work sometimes appe ared to run equivalent to that of Foucault, an erstwhile anthropologist and former student of Levi-Strauss, he was in many respects a characteristically cut theorist.However he distanced himself from the objectivism of structural anthropology, at the like time as re maining mulishly opposed to to post-structuralist deconstruction (Bourdieu, 1977 Bourdieu, 1984, p. 495). Furtherto a greater extent, his work active really directly with both red ink and Weberian traditions in cordial surmise. One critic has even observed that it is best understand as the attempt to push bod analysis beyond Marx and Weber (Eder, 1993, p. 63).Definitely, if hyper particular theory is described in impairment of its objective to change the world, the n Bourdieu was as significant a theorist as any. Throughout the late 1990s, he appeared as by far the closely kn have got academic intellectual to join in active solidarity with the new antiglobalisation movements. His La Misere du monde, rootage published in volume in 1993 and in paperback in 1998, turned out to be a bestseller in France and a main source of political motivation to the movement, both in the trustworthy and in its incline translation as The Weight of the World.He was directly implicated in militant antiglobalisation activism, speaking at stool meetings of striking railway workers in 1995 and slothful workers in 1998 (Bourdieu, 1998, pp. 24n, 88n) he initiated the 1996 formally solicit for an Estates world-wide of the Social Movement and its may Day 2000 successor, the petition for a pan-European Estates General he confounded the radical Raisons dagir radical and its associated print house he everyplacetly called for a left Left (Bourdieu, 1998a) and he was a regular contri scarceor to the radical French monthly, Le Monde diplomatique.We may furnish that, like Marx, Bourdieu attached a distinguishing furnish to what is still his best-known work preeminence A Social Critique of the general opinion of Taste (Bourdieu, 1984). Bourdieus re adjustation as a sociological thinker revolves around the theory of formula, in which he essay to theorise human fondity as the number of the tactical action of individuals operating at heart a constraining, however non determining, context of values.Notably, the term Bourdieu coined to explained this was the habitus (Bourdieu, 1977), by which he meant an acquired system of generative schemes objectively alter to the particular conditions in which it is constituted (p. 95). It is at the resembling time structured and structuring, materially produced and very frequently generation-specific (pp. 72, 78). Elsewhere, he explained it as a kind of transforming machine that leads us to reprod uce the amicable conditions of our own production, but in a relatively irregular way (Bourdieu, 1993, p.87). Like Marx and Weber, Bourdieu thinks contemporary capitalistic societies to be family line societies. However for Bourdieu, their plethoric allele and dominated framees are discernible from all(prenominal) other not simply as a division of economicalalals, however as well as a matter of habitus social phratry, understood as a system of objective determinations, he insisted, must be brought into relation with the class habitus, the system of trends (partially) common to all products of the equal structures (Bourdieu, 1977, p. 85).Bourdieus most elongatedly cited study, though, and undoubtedly the most powerful in pagan studies, has been Distinction, a work that takes as the object of its limited review specifically the same kind of tall modernism as that privileged in capital of Kentucky schooling aesthetics. Where Adorno and Horkheimer had insisted on a radic al dispersistence amidst capitalist galvanic pile culture as well as avant-garde modernism, Bourdieu would focus on the latter(prenominal)s own profound complicity with the social structures of power and mastery.The sustain was footed on an extremely thorough sociological survey, conducted in 1963 and in 1967/68, by interview and by ethnographical observation, of the heathenish preferences of everywhere 1200 people in Paris, Lille and a small French provincial townspeople (Bourdieu, 1984, p. 503). Examining his sample data, Bourdieu recognized three main zones of taste legitimate taste, which was most extensive in the educated sections of the principal class middle-brow taste, more extensive among the middle classes and popular taste, prevalent in the working classes (p.17). He characterised lawful taste mainly in terms of what he named the aesthetic disposition to state the absolute primacy of form everyplace function (pp. 28, 30). Artistic and social unexpendedity is co nsequently inextricably interrelated, he argued The clear gaze implies a splinter with the run-of-the-mine attitude towards the world which, as such, is a social break (p. 31).The popular aesthetic, by contrast, is based on the affirmation of continuity between art and life and a deeprooted demand for participation (p. 32). The distinguishing detachment of this small gaze, Bourdieu argued, is part of a more general disposition towards the gratuitous and the free, in which the affirmation of power over a dominated necessity implies a claim to legitimate superiority over those who remain dominated by middling interests and urgencies (pp.556). Bourdieus general sociology had posited that, without exception, all human consecrates can be treated as economic practices directed towards the maximizing of material or symbolic profi (Bourdieu, 1977, p. 183). Therefore his leaning to view the intelligentsia as self-interested traders in ethnical capital. For Bourdieu, it followed that professional intellectuals were best measured as a subordinate fraction of the same social class as the bourgeoisie.Defining the leading class as that possessed of a high overall volume of capital, whatsoever its source whether economic, social or heathen he located the intellectuals in the dominant class by virtue of their get to to the latter. The dominant class therefore comprises a dominant fraction, the bourgeoisie proper, which excessively controls economic capital, and a dominated fraction, the intelligentsia, which disproportionately controls cultural capital. The most on the face of it disinterested of cultural practices are thus, for Bourdieu, essentially material in character.Even when analysing the more purely esthetic forms of literary activity, the anti-economic economy of the champaign of restricted as opposed to big cultural production, he noted how symbolic, long profits are ultimately reconvertible into economic profits (Bourdieu, 1993a, p. 54) and how avant-garde cultural practice remained dependent on the possession of stiff economic and social capital (p. 67). Finally, Bourdieu comes to question current practices in the visual arts. He sees the current bureaucratization and commercialization of the limited modernist report as a threat to elegant autonomy.He registers with disquiet trusted recent developments which put at risk the precious conquests of the elitist artists-the suffusion of art and money, through new patterns of patronage, the exploitation dependence of art on bureaucratic control, plus the consecration through prizes or honours of plant successful merely with the wider public, on board the long-cycle modernist works cherished by artists themselves. Bourdieus recap of viewlized exquisite disinterestedness has been incorrectly reinterpreted as a theory of extensive self-centred domination, not least by the consecrated avant-garde.Bourdieus socio-analysis of the artists has shown, in spite of charismatic ideology, that in practice the Impressionists and subsequent modernists lived a comfortable creation by the time of their middle age, and that commonly gallery owners or dealers sold their works on their behalf, therefore relieving them of attention to the Vulgar needs of material existence. Bourdieu as well accounts for certain recurrent features of the closed worlds of art, for example the social reality of artists struggles over cultural government activity, which the spiritualist account cannot explain.Contrary to the orthodox expectations of sublimated damage, Bourdieu cites legion(predicate) examples where the conflicts between artists over their specifically artistic interests typesetters cased open violence the Surrealists fight, in which Andre Breton bust a fellow artists arm, is a drive in point. Nor did the idealized expectations of art lay off numerous cultural producers collaborating with the Vichy regime in the 1940s. In The Rules of Art, Bourdieu resumed ma ny of the themes first broach in Distinction, particularly the role of cultural discernment as a target of class position.Here he elucidated how Flaubert, Baudelaire and Manet had been critical to the founding of an autonomous artistic reach of salons, publishing houses, producers, commentators, critics, distributors, and all that and to the establishment of a idea of art for arts sake, which measured legitimacy as disinterestedness. For Bourdieu, the latter concept tag the genesis of the modern artist or writer as a fulltime professional, give to ones work in a primitive and exclusive manner, indifferent to the exigencies of politics and to the injunctions of morals (Bourdieu, 1996, pp.767). This new artistic field had created a zone of autonomy, free from both the trade and politics, in its heroic phase, throughout the latter part of the 19th century. But in the 20th century, Bourdieu argued, modernist art had developed not as a critique of the press cage of instrumenta l rationality, however as a function of the power games of the dominant classes, its capacities for critical distance gradually erode through cooption by both the crisscrosset place and the state education system.Bourdieu detected analogously interested processes at work in the academic intelligentsia. The academic profession is a competitive struggle for authenticity and cultural distinction, he elucidated, which functions to reproduce the wider structures of social class inequality whether applied to the world, to students, or to academics themselves, academic taxonomies are a machine for transforming social classifications into academic classifications (Bourdieu, 1988, p.207). Afterwards he would song the central significance of the elite have schools, the alleged grandes ecoles, to the power of the French social and economic elite, showing how their credentialism operated as a kind of state magic for a supposedly rationalised society (Bourdieu, 1996, p. 374).Tracing the gro wing incidence of academic credentials among the chief executives of the transgress 100 French companies, he cogitate that the obvious substitution of academic for place titles in fact performed a vital legitimating function company heads no bimestrial appear the heirs to a fortune they did not create, he wrote, but kinda the most exemplary of self-made men, positive by their merits to wield power in the name of competence and intelligence (p. 334).Where the Frankfurt School had worked with a model of theory as overtly critical, Bourdieu tended to have an action on a quasipositivistic objectivism, in browse that the moment of critique was often out of sight behind a mask of scientific objectivity. In The Weight of the World, he used a mixture of ethnographic interviews and sociological commentary to mount a stunning condemnation of contemporary utilitarianism in the shape of economic liberalism as creating the preconditions for an strange development of all kinds of or dinary suffering (Bourdieu et al. , 1999).However even here, in his most explicitly engaged work, he still insisted that sociological science could itself uncover the possibilities for action that politics will require exploring (p. 629). Where the Frankfurt School had conceived of intellectuals as considerably productive of critical sensibility, Bourdieu tended to detect merely material self-interest. This shield of reflexive critique is essential, he argued, to break with the habits of thought, cognitive interests and cultural beliefs bequeathed by several(prenominal) centuries of literary, artistic or philosophical faith (Bourdieu 2000, p. 7).However such cynicism can easily cause a radical overestimation of the generative powers of the social status quo. Even though Bourdieus vocabulary of cultural capital and symbolic profits has sometimes misled his readers, his persistence on the complex motives in artists desire to make a mark does not permit him to forget the very import ant differences between the artistic field and the field of capitalist power. Bourdieu argues that the characteristic reputation of artistic and other cultural palm is that they exist in the form of mutual gift exchange somewhat than cosmos animated by money.Further, he does not lessen artists to their class position, nor does he cut through that artists may certainly be singular figures. Indeed, the comparison across the limited and spread out artistic fields sharpens approval of the differences between the autonomous artists and others. The sociological analysis of the artworks, which illustrates how they are necessitated by social situation and artistic position-taking, can therefore become a piquant sauce which serves to intensify the pleasures of the works. References Bourdieu, P (1977), delimit of a Theory of Practice, trans. R.Nice, Cambridge University concentrate, Cambridge. ___(1984), Homo academicus, English edn 1988a, Homo Academicus, trans. P. Collier, commandm ent Press, Cambridge ___(1988), Lontologie politique de Martin Heidegger, English edn 1991b, The political Ontology of Martin Heidegger, trans. P. Collier, Polity Press, Cambridge ___(1993), Concluding remarks for a sociogenetic mind of cultural works in Bourdieu searing Perspectives, eds C. Calhoun, E. LiPuma and M. Postone, Polity Press, Cambridge ___(1993a), The Field of ethnic Production Essays on Art and Literature, ed. and introd. R. Johnson, Polity Press, Cambridge___(1996), Sur la television, English edn 1998c, On Television, trans. P. P. Ferguson, New Press, New York ___(1998), Contre-feux. Propos pour servir a la resistance contre linvasion neo-liberale, English edn 1998b, Acts of safeguard Against the New Myths of Our Time, trans. R. Nice, Polity Press, Cambridge ___(1998a), La domination masculine, English edn 2001, Masculine Domination, trans. R. Nice, Stanford University Press, Stanford, CT ___and L. Wacquant (1999), On the cunning of imperialist reason Theory, re finement and Society, 16/1 ___ (2000) Pascalian Meditations. Cambridge Polity Press Eder, K (1993). Th